Effects of Resistance Training on the Inflammatory Profile of Healthy Elderly People of Both Sexes: Case Series
REF / JPE 2021; 90, 2
pdf (Português (Brasil))

Keywords

physical exercise
strength training
inflammation

How to Cite

Braga, P., Maria Peixoto, L. ., Cruz de Oliveira, E., Mauro de Castro Pinto, K., Kappes Becker Oliveira, L. ., & Barbosa Coelho, D. . (2021). Effects of Resistance Training on the Inflammatory Profile of Healthy Elderly People of Both Sexes: Case Series. Journal of Physical Education, 90(2), 134–148. https://doi.org/10.37310/ref.v90i2.2746

Abstract

Introduction: Low-grade chronic inflammation is caused by aging and interferes with most tissues’ of body metabolism. The literature indicates that the practice of strength training reduces the harmful effects caused by chronic inflammation (diabetes, hypertension and sarcopenia). However, biological aspects can stimulate different responses in men and women.

Objective: To evaluate the effect of long-term strength training (19 weeks) on inflammatory biomarkers CRP and IL-8, strength and anthropometric parameters in apparently healthy elderly people of both sexes.

Methods: Exprimental longitudinal study (19 weeks) in which 40 physically active and healthy elderly (63.90±5.80 years) participated, 14 men and 26 women. The intervention included a strength training program involving large muscle groups, performed three times a week on non-consecutive days, training intensity that progressed 60% to 85% of one repetition maximum (1RM) and 8 to 15 repetitions. Plasma levels of C-reactive protein (CRP) and interleukin-8 (IL-8) were assessed in the first and last week of intervention. The case series format describes the characteristics of a group of patients with a specific disease or who underwent a certain procedure, thus, there was no presence of a control group.

Results: No differences in CRP and IL-8 concentrations were observed in either sex after the intervention.

Conclusion: Resistance training with progressive intensity of long duration (19 weeks) did not change the concentrations of serum inflammatory markers (IL-8 and CRP) in healthy elderly.

https://doi.org/10.37310/ref.v90i2.2746
pdf (Português (Brasil))

References

Cruz-Jentoft AJ, Bahat G, Bauer J, Boirie Y, Bruyère O, Cederholm T, et al. Sarcopenia: Revised European consensus on definition and diagnosis. Age Ageing. [Online] 2019;48(1):16–31. Available from: doi:10.1093/ageing/afy169.

Confortin SC, Ono LM, Barbosa AR, Orsi E. Sarcopenia e sua associação com mudanças nos fatores socioeconômicos, comportamentais e de saúde: Estudo EpiFloripa Idoso. Cadernos de Saúde Pública. [Online] 2018;34. Available from: https://doi.org/10.1590/0102-311x00164917.

Jo E, Lee SR, Park BS, Kim JS. Potential mechanisms underlying the role of chronic inflammation in age-related muscle wasting. Aging Clinical and Experimental Research. [Online] 2012;24(5):412–22. Available from: doi: 10.3275/8464.

Alway SE, Mayers MJ, Mohamed JS. Regulation of satellite cell function in sarcopenia.Frontiers in Aging Neuroscience. [Online] 2014;22(6). Available from: doi: 10.3389/fnagi.2014.00246.

Margutti KMM, Schuch NJ, Schwanke CHA. Inflammatory markers, sarcopenia and its diagnostic criteria among the elderly: a systematic review. Revista Brasileira de Geriatria e Gerontologia. [Online] 2017;20(3):441–53. Available from: doi: 10.590/1981-22562017020.160155.

Piovesan R, Ribeiro S. Inflammaging: Inflamação sistêmica e de baixo grau decorrente do envelhecimento. Sociedade Brasileira de Geriatria e Gerontologia. [Online] 2016;43(14):244-54.

Guedes JM, Pireri BLS, Luciano TF, Marques SO, Guglielmo LGA, Souza CT. Exercícios físicos de resistência, hipertrofia e força muscular reduzem igualmente adiposidade, inflamação e resistência à insulina em camundongos obesos. Einstein. [Online] 2018;16(4):1-9. Available from: doi: 10.31744/einstein_journal/2020AO4784.

Villacorta H, Masetto AC, Mesquita ET. C-reactive protein: An inflammatory marker with prognostic value in patients with decompensated heart failure. Arquivos Brasileiros de Cardiologia. [Online] 2007;88(5):585-9. Available from: doi: 10.1590/s0066-782x2007000500014.

Fernandes AC, Gazzinelli A, Velásquez-Meléndez G. Associação entre medidas de adiposidade, variáveis demográficas e bioquímicas com os níveis séricos de proteína C-reativa em população rural. Archivos Latinoamericanos de Nutrición [Online] 2009;59(1):54-60.

Garcia VP, Rocha HNM, Sales ARK, Rocha NG, Nóbrega ACL. Diferenças na Proteína C Reativa Ultrassensível associado ao gênero em Indivíduos com Fatores de Risco da Síndrome Metabólica. Arquivos Brasileiros de Cardiologia. [Online] 2016; 106(3) Available from: doi: https://doi.org/10.5935/abc.20160027

Rech A. Efeitos do treinamento de força sobre a saúde vascular e sinalizadores inflamatórios em indivíduos idosos diabéticos do tipo 2. Universidade Federal do Rio Grande do Sul. 2017; Available from: https://lume.ufrgs.br/handle/10183/172961 [Accessed: 10th September 2021].

García-Hermoso A, Sánchez-López M, Escalante Y, Saavedra JM, Martínez-Vizcaíno V. Exercise-based interventions and C-reactive protein in overweight and obese youths: A meta-analysis of randomized controlled trials.Pediatric Research. Nature Publishing Group; [Online] 2016;522–7. Available from: doi: 10.1038/pr.2015.274.

Santiago LÂM, Lima Neto LG, Santana PVA, Mendes PC, Lima WKR, Navarro F. Treinamento resistido reduz riscos cardiovasculares em idosas. Revista Brasileira de Medicina do Esporte. [Online] 2015;21(4):261–5.

Donges CE, Duffield R, Drinkwater EJ. Effects of resistance or aerobic exercise training on interleukin-6, C-reactive protein, and body composition. Medicine & Science in Sports & Exercise. [Online] 2010;42(2):304–13. Available from: doi: 10.1249/MSS.0b013e3181b117ca.

Nikseresht M, Sadeghifard N, Agha-Alinejad H, Ebrahim K. Inflammatory markers and adipocytokine responses to exercise training and detraining in men who are obese. The Journal of Strength & Conditioning Research. [Online] 2014;28(12):3399–410. Available from: doi:10.1519/jsc.0000000000000553.

Fernandes AC, Gazzinelli A, Velásquez-Meléndez G. Associação entre medidas de adiposidade, variáveis demográficas e bioquímicas com os níveis séricos de proteína C-reativa em população rural. Archivos Latinoamericanos de Nutrición [Online] 2009;59(1):54-60.

Garcia VP, Rocha HNM, Sales ARK, Rocha NG, Nóbrega ACL. Diferenças na Proteína C Reativa Ultrassensível associado ao gênero em Indivíduos com Fatores de Risco da Síndrome Metabólica. Arquivos Brasileiros de Cardiologia. [Online] 2016; 106(3) Available from: doi: https://doi.org/10.5935/abc.20160027.

Zwahlen R, Walz A, Rot A. In vitro and in vivo activity and pathophysiology of human interleu-kin-8 and related peptides. International Review of Experimental Pathology. [Online] 1993; 34:27-42.

Akerstrom T, Steensberg A, Keller P, Keller C, Penkowa M, Pedersen BK. This article has been retracteded Exercise induces interleukin‐8 expression in human skeletal muscle. The Journal of Physiology. [Online] 2005;563(2):507–16. Available from: doi: 10.1113/jphysiol.2011.213231.

Gonçalves I. Efeito do treinamento combinado em idosos nas variáveis de capacidade funcional, fisólógicas, bioquimícas e de marcadores inflamatórios. São Paulo:Universidade Federal de Mogi das Cruzes;2013.

Nicioli C. Efeitos do treinamento de musculação em circuito sobre a aptidão cardiorespiratória e citocinas plasmaticas IL-6,IL8,IL-10,TNF,IL-1 β e IL-12p70 em mulheres saudáveis. São Paulo: Universidade Federal de São Carlos; 2008.

Buford T, Cooke M, Willoughby D. Resistance exercise-induced changes of inflammatory gene expression within human skeletal muscle. European Journal of Applied Physiology. [Online] 2009;107:463–71. Available from: doi: 10.1007/s00421-009-1145-z.

Miot HA. Tamanho da amostra em estudos clínicos e experimentais. Jornal Vascular Brasileiro. [Online] 2011;10(4):275–8. Available from: doi:10.1590/S1677-54492011000400001.

Lohman TG, Roche AF, Martorell R. Anthropometric standardization reference manual. Human Kinetics Books. [Online] 1988. Available from: doi:10.1249/00005768-199208000-00020

Durnin JVGA, Womersley J. Body fat assessed from total body density and its estimation from skinfold thickness: measurements on 481 men and women aged from 16 to 72 years. British Journal of Nutrition. [Online] 1974;32(1):77–97. Available from: doi: 10.1079/bjn19740060.

Caltran P, Silva SC, Pope S, Fornari JV, Barnabé AS, Arçari DP et al. Utilização do índice de massa corporal para estimativa do estado nutricional de funcionáriosde uma empresa do ramo químico. Educação em Foco. [Online] 2013; 103-112.

Brzycki M. Strength Testing—Predicting a One-Rep Max from Reps-to-Fatigue. Journal of Physical Education Recreation & Dance. [Online] 1993;64(1):88–90. Available from: doi:10.1080/07303084.1993.10606684.

Chodzko-Zajko WJ, Proctor DN, Singh MAF, Minson CT, Nigg CR, Salem GJ, et al. Physical activity for older adults. Medicine & Science in Sport & Exercise. [Online] 2009;41:1510-1530. Available from: doi:10.1249/MSS.0b013e3181a0c95c.

Lio C. e Latham, N.K. Progressive resistance strenght training for improving physcal functions in older adults. Cochrane database of systematic reviews. [Online] 2009 (3): 1-211 Available from: doi: 10.1002/14651858.CD002759.pub2.

Oliveira LF, Rodrigues PAS. Waist circumference: measurement protocols and their practical applicability. Nutr - Revista de Nutrição e Vigilância em Saúde. [Online] 2016;3:90–5. Available from: doi: 10.5935/2359-4802.20180080

Romieu M, Orsetti A, Jaffiol C. Comparaison de la reponse endocrinienne sous deux modes d'anesthesie:neroleptanalgesie de type chloprothixene dextromoramide et anesthesie veineuse de type alfadione fentanyl. Annales de l'Anesthesiologie Francaise. [Online] 1975;16(9):711–20.

Pagotto VI, Ferreira Santos KI, Gomes Malaquias SI, Márcia Bachion MI, Aparecida Silveira EI. Circunferência da panturrilha: validação clínica para avaliação de massa muscular em idosos Calf circumference: clinical validat Pagotto, V. I., Ferreira dos Santos, K. I., Gomes Malaquias, S. I., Márcia Bachion, M. I., & Aparecida Silveira, E. I. (2018). Revista Brasileira de Enfermagem . [Online] 2018;71(2):343–50.

Della Gatta PA, Garnham AP, Peake JM, Cameron-Smith D. Effect of exercise training on skeletal muscle cytokine expression in the elderly. Brain Behavior and Immunity. [Online] 2014;39:80–6. Available from: doi: 10.1016/j.bbi.2014.01.006.

Petersen AMW, Pedersen BK. The anti-inflammatory effect of exercise. Journal of Applied Physiology. [Online] 2005;98(4):1154–62. Available from: doi:10.1152/japplphysiol.00164.2004

FortiLN, RoieEV, NjeminiR, CoudyzerW, BeyerI, Delecluse C, Bautmansi. Effects of resistance training at different loads on inflammatory markers in young adults. European Journal of Applied Physiology. [Online] 2017, Available from; doi:10.1007/s00421-017-3548-6.

Mavros Y, Kay S, Simpson KA, Baker MK, Wang Y, Zhao RR, et al. Reductions in C-reactive protein in older adults with type 2 diabetes are related to improvements in body composition following a randomized controlled trial of resistance training . Journal Cachexia, Sarcopenia and Muscle. [Online] 2014;5(2):111–20. Available from: doi:10.1007/s13539-014-0134-1.

Tomeleri CM, Ribeiro AS, Souza MF, Schiavoni D, Schoenfeld BJ, Venturini D, et al. Resistance training improves inflammatory level, lipid and glycemic profiles in obese older women: A randomized controlled trial. Experimental Gerontology . [Online] 2016;84:80–7. Available from: doi: 10.1016/j.exger.2016.09.005.

Martins RA, Veríssimo MT, Coelho E Silva MJ, Cumming SP, Teixeira AM. Effects of aerobic and strength-based training on metabolic health indicators in older adults. Lipids in Health and Disease. [Online] 2010;9:1–6. Available from: doi: 10.1186/1476-511X-9-76.

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